The MOUSE ANTI HUMAN CD266 Antibody from MyBioSource.com is a Mouse Monoclonal antibody to CD266, Fn14, and TNFRSF12A. This antibody recognizes Human, Mouse, and Rat antigen. The MOUSE ANTI HUMAN CD266 Antibody has been validated for the following applications: Flow Cytometry, Immunohistochemistry, and Western Blot.
Description
Mouse anti Human CD266 antibody, clone ITEM-4 recognizes human CD266, otherwise known as Fn14/TWEAK Receptor, a 14kDa type I transmembrane glycoprotein and member of the tumour necrosis factor receptor superfamily (TNFRSF12A) expressed by a variety of tissues, including the heart, lung and kidney, and at elevated levels by human brain and liver tumours. The interaction between CD266 and its ligand CD255 (TWEAK), induces the proliferation and migration of endothelial cells and also angiogenesis, and studies have shown that CD255-induced apoptosis of some tumour cell lines is mediated by CD266 (Nakayama et al. 2003). Mouse anti Human CD266 antibody, clone ITEM-4 is cross-reactive with mouse CD266, and also with Rat-1 cells in flow cytometry